Psychiatr. praxi. 2013;14(2):62-65

Dissociative disorders and possibilities of psychopharmacotherapy

MUDr.Alena Večeřová-Procházková
Psychiatrická ambulance, Gyncare s. r. o., Praha

The pathological dissociation is manifested primarily in loss of normally integrated functions of memory, identity and consciousness, in

situations where the individual psyche is not able to cope with an unacceptable mental content. Amnesia, depersonalization, derealisation

and identity disturbances are considered as the core symptoms The wide range of comorbid symptoms include affective symptoms,

anxiety, psychotic misperception and impulse-dyscontrol.The therapeutic method of choice is psychotherapy, psychopharmacotherapy

is targeted to reduce or eliminate comorbid symptoms. SSRIs and SNRI antidepressants, second -generation antipsychotics, anticonvulsants

and mood stabilisers are recommended.

Keywords: dissociation, psychopharmacotherapy, comorbidity

Published: April 1, 2013  Show citation

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Večeřová-Procházková A. Dissociative disorders and possibilities of psychopharmacotherapy. Psychiatr. praxi. 2013;14(2):62-65.
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    References

    1. Bob P, Vymětal J. Psychobiologické reakce na stres a trauma. Česká a slovenská psychiatrie 2005; 101: 425-432.
    2. Nerad JM, Neradová L. Příspěvek k diskuzi o problematice disociativních stavů s přihlédnutím k dílu Pierra Janeta (1859-1947), Čes a Slov Psychiat. 2005; 101(2): 98-104.
    3. Bremner JD, Krystal JH, Charney DS, Southwick SM. Neural Mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the, ,false memory syndrome". Am J Psychiatry 1996; 153(7 Suppl): 71-82. Go to original source... Go to PubMed...
    4. Soukup J. Disociativní procesy a poruchy v dětství a adolescenci (Výzkum pomocí dotazníku A-DES). Praha: FF UK, 2005. Rigorózní práce. Dostupné z: http://www.zkola.cz/zkedu/rodiceaverejnost/socialnepatologickejevyajejichprevence/psychickeproblemy/21240.aspx.
    5. Sharon I. Dissociative disorders http://emedicine.medscape.com/article/294508-overview#showall.
    6. Spiegel D, Loewenstein RJ, Lewis-Fernandez R, Sar V, Simeon D, Vermetten E, Cardeňa E, Dell PF. Dissociative disorders in DSM-V; Depression and Anxiety 2001; 28: 824-852. Go to original source... Go to PubMed...
    7. Smolík P. Duševní a behaviorální poruchy. 2. revidované vydání. Praha, Maxdorf, 2002.
    8. Ptáček R. Obecně psychologické a osobnostní souvislosti disociace, Doktorská disertační práce, Brno 2006.
    9. Herman E, Hovorka J, Praško JP, Nežádal T, Bajaček M, Doubek P. Disociativní poruchy v praxi; Psychiatr. Prax 2009; 10(1): 13-18
    10. Grambal A, Grambalová Z, Pastucha P, Praško JP. Farmakoterapie disociativních poruch, Psychiat pro praxi 2010; 11(3): 99-102.
    11. Hunter EC, Sierra M, David AS. The epidemiology of depersonalisation and derealisation: a systematic review, Soc psychiatr Psych Epidemiol 2004; 39(1): 9-18. Go to original source... Go to PubMed...
    12. Rhawn J. Traumatic Stress: Dissociative Amnesia, Out-ofbody Hallucinations, Flashbacks, PTSD, Catatonia And Paralytic Fear, in Neuropsychiatry, Neuropsychology, Clinical Neuroscience, 3rd Edit, 2005, dostupné z http://brainmind.com/publications.html.
    13. Steinberg M. The Interviewer's Guide to the Structured Clinical Interview for DSM-IV Dissociative Disorders- Revised. Washington, D.C., American Psychiatric Press, 1994.
    14. Ellason JW, Ross CA, Fuchs DL. Lifetime axis I and II comorbidity and childhood trauma history in dissociative identity disorder. Psychiatry 1996; 59: 225-265. Go to original source... Go to PubMed...
    15. Hort Vl, Hrdlička M, Kocourková J, Malá E, a kol. Dětská a adolescentní psychiatrie. Praha, Portál, 2000.
    16. Saxe GN, van der Kolk BA, Berkowitz R, Chinman G, Hall K, Lieberg G, Schwartz J. Dissociative disorders in psychiatric inpatients. American Journal of Psychiatry 1993; 150: 1037-1042. Go to original source... Go to PubMed...
    17. van der Kolk BA, Pelcovitz D, Roth S, et al. Dissociation, somatization, and affect dysregulation: the complexity of adaptation of trauma. Am J Psychiatry 1996; 153(7 Suppl): 83-93. Go to original source... Go to PubMed...
    18. Post RM, Weiss SR. A spekulative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala - kindled seizures. MolNeurobiol 1996; 13(1): 33-60. Go to original source...
    19. Vermetten E, Dorahy MJ, Spiegel D. Traumatic dissociation: neurobiology and treatment, 2007, Psychiatric Association Publishing.
    20. Simeon D, Guralnik O, Schmiedler J, et Knutelska M. Fluoxetine therapy in depersonalisation disorder: randomised controlled trial, Br J Psychiatry 2004; 185(1): 31-36. Go to original source... Go to PubMed...
    21. Marshall RD, Lewis-Fernandez R, Blanco C, et al. A controlled trial of paroxetine for chronic PTSD, dissociation and interpersonal problems in mostly minority adults, Depress Anxiety 2007; 24(2): 77-84. Go to original source... Go to PubMed...
    22. Hollander E, Liebowitz MR, DeCaria C, et al. Treatment of depersonalization with serotonin reuptake blockers. J Clin Psychopharmacol. 1990; 10(4): 200-203. Go to original source...
    23. Desarkar P, Das A, Sinha VK. Duloxetine for childhood depression with pain and dissociative symptoms, Eur Child Adolesc Psychiatry 2006; 15(8): 496-499. Go to original source... Go to PubMed...
    24. Asnis GM, Kohn SR, Henderson M, Brown NL. SSRIs versus non-SSRIs in post-traumatic stress disorder: an update with reommendations. Drugs, 2004; 64(4): 338-404. Go to original source... Go to PubMed...
    25. Simeon D, Knutelska M. An open trial of naltrexone in the tratment of depersonalization disorder JCLin Psychopharmacol 2005; 25(3): 267-270. Go to original source... Go to PubMed...
    26. Nuller YL. Depersonalization-symptoms, meaning, therapy. Acta Psychiatr Scand. 1982; 66: 451-458. Go to original source... Go to PubMed...
    27. Bohus MJ, Landwehrmeyer GB, Stiglmayr CE, et al. Naltrexone in the treatment of dissociative symptoms in patients with borderline personality disorder: an open-label trial. J Clin Psychiatry 1999; 60(9): 598-603. Go to original source... Go to PubMed...
    28. Paris J. Recent advances in the treatment of borderline personality disorder. Can J Psychiatry 2005; 50(8): 435-441. Go to original source... Go to PubMed...
    29. Reich DB, Winternitz S, Hennen J, et al. A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women. J Clin Psychiatry 2004; 65(12): 1601-1606. Go to original source... Go to PubMed...
    30. Sutherland SM, Davidson JR. Pharmacotherapy for posttraumatic stress disorder, Psychiatr Clin North Am, 1994; 17(2): 409-423. Go to original source... Go to PubMed...
    31. Sierra M. Depersonalisation disorder: pharmacological approaches. Expert Rev Neurother 2008; 8(1): 19-28. Go to original source... Go to PubMed...

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