Psychiatr. pro Praxi, 2005; 4: 201-202

Benefity zámeny antidepresív u pacientov so sexuálnymi dysfunkciami

MUDr. Radovan Vaškovský
Psychiatrické oddelenie, Fakultná nemocnica Nitra

Problematika výskytu sexuálnych dysfunkcií (SD) pri liečbe antidepresívami (AD) je pomerne častý a závažný problém, i keď stále ešte nie dostatočne sledovaný vrámci komplexnej starostlivosti o pacienta. Tento fakt môže spôsobiť nielen parciálnu odpoveď na liečbu, ale môže byť i príčinou drop-outu pacienta k spomínanej liečbe.

Podľa doposiaľ známych skutočností, zdá sa, že by mohla existovať skupina antidepresív s vyšším rizikom výskytu SD, kde by sme mohli zaradiť preparáty s prevažným serotoninergným pôsobením. Patria sem preparáty typu TCA, IMAO, SSRI a SNRI. Naproti tomu je skupina antidepresív, kde ich pôsobenie je predovšetkým dopaminergné, čiastočne noradrenergné, respektíve ovplyvňuje iba selektívne špecifické serotonergné receptory (s priaznivým pôsobením na sexuálne fungovanie). Túto skupinu antidepresívnych preparátov s nižším výskytom SD tvoria RIMA (moklobemid), NaSSA (mirtazapin), SARI (trazodon), SRE (tianeptin), NDRI (bupropion), NARI (reboxetin) a extrakt ľubovníka bodkovaného (Hypericum perforatum). Práca hodnotí prínosy zámeny antidepresíva (prevedenia pacienta na) za antidepresívum s nižším rizikom výskytu sexuálnych dysfunkcií.

Published: February 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Vaškovský R. Benefity zámeny antidepresív u pacientov so sexuálnymi dysfunkciami. Psychiatr. praxi. 2005;9(4):201-202.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Ashton AK, Bennett RG. Sildenafil treatment of serotonin reuptake inhibitor-induced sexual dysfunction [letter]. J Clin Psychiatry. 1999; 60: 194-195. Go to original source... Go to PubMed...
    2. Baldwin D. Depresion and sexual dysfunction. Br Med Bull; 2001; 57: 81-99. Go to original source... Go to PubMed...
    3. Balon R, Yeragani VK, Phol R, Ramesh C, Vikram K. Sexual dysfunction during antidepressant treatment. J Clin Psychiatry 1993; 54: 209-212.
    4. Casper RC, Redmond F, Kutz MM, et al. Somatic symptoms in primary affectiuve disorders: presence and relationship to the classification of depression. Arch Gen Psychiatry 1985; 42: 1098-1104. Go to original source... Go to PubMed...
    5. Clayton AH, McGarvey EL, Abouesh AL, Pinkerton RC. Substitution af an SSRI with bupropion sustained release following SSRI-induced sexual dysfunction. J Clin Psychiatry; 2002(a) 62: 185-190. Go to original source... Go to PubMed...
    6. Ferguson JM. The effects of antidepressants on sexual functioning in depressed patients: a review. J Clin Psychiatry 2001; 62(suppl 3): 22-34.
    7. Maršálek M. Sexuální dysfunkce pri léčbe antidepresivy. Psychiatrie pro praxi; 2003; 3: 94-100.
    8. McGahuey CA, Gelenberg AJ, Laukes CA, et al. The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther 2000; 26: 25-40. Go to original source... Go to PubMed...
    9. Montejo AL, Llorca G, Izquierdo JA, Roco-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: A prospective multicenter study of 1022 outpatients. J Clin Psychiatry 2001; 62 [suppl 3]: 10-21.
    10. Nurnberg HG, Seidman SN, Gelenberg AJ, Fava M, Rosen R, Shabsigh R. Depression, Antideprerssant thierapies, and erectile dysfunction: Clinical trials of sildenafile citrate (Viagra(R)) in treated and untreated patients with depression. Urology; 2002; 60 Suppl 2B) 30: 58-66. Go to original source... Go to PubMed...
    11. Zajecka J. Strategies for the Treatment of Antidepressant-Related Sexual Dysfunction. J Clin Psychiatry 2001; 62 (suppl 3): 35-43.

    Return to the content


    Psychiatry for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.