Psychiatr. pro Praxi, 2005; 2: 80-82

ANTIPSYCHOTIC DRUGS - A RISK FACTOR FOR VENOUS THROMBOEMBOLISM?

MUDr. Jiří Masopust¹, MUDr. Ing. Aleš Urban¹, MUDr. Radovan Malý Ph.D²

¹ Psychiatrická klinika LF UK a FN Hradec Králové

² I. interní klinika Fakultní nemocnice v Hradci Králové

A treatment with antipsychotic drugs is associated with an increased risk of a venous thrombosis. The biological mechanism responsible for this possible adverse drug reaction is unknown, but the number of explaining hypotheses is growing. Some abnormalities of coagulation or a stasis of blood flow are considered. The influence of the life-style of patients with the long-term antipsychotic therapy can’t be neglected. In most cases, there are additional risk factors. Double-blind studies still failed to prove a possible connection between an increased risk of a venous thromboembolism and the treatment with antipsychotics drugs as yet. We present case-reports related to this topic.

Keywords: Key words: antipsychotics, venous thrombosis, pulmonary embolism, antiphospholipids antibodies.

Published: February 1, 2006  Show citation