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2025;26(2):116-1221916804001074386128172185229271295338360374412446485515553591635
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PROFIL1677200012660124199256289345
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farmakokinetiky55536001062867102157197233272307325366398432449485524
vybraných109536001063675111147189230267300341
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farmakokinetiky112292002988220629650062675588910181086122513501438150416331764
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pacientů52811800298144269376441567707793932
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ledvin45421180029866192335461526665
Mgr.3401580013793158200223
Michaela5851580013794125174239297356387445
Jelínková1,10521580013746104135165230290352409467151115900803615461580013729
PharmDr.15971580013764127185227322399441464
Jan20831580013746104168
Miroslav22741580013793124166229277308366423
Hartinger,27191580013776134176219250314379437480503
Ph.D.2324415800137641281572352613508159008036
1Oddělení3401740078333711740013376139200255281336397422
klin.816174001335279104164187
farmacie,1026174001333285121212265314338393415
Fakultní14641740013354102153213239274335360
nemocnice18471740013361116208268318378403452505
Královské2375174001336097150175236287330381434
Vinohrady,2832174001336288148209270305358420471489
Farmakologický33441740013353102137229281332391417477539564613663718
ústav40861740013360103140193244
1.4353174001335674
LF44501740013352104
UK45781740013371130
a47311740013353
VFN,48081740013361115185208
Praha5040174001335893145206258
2Farmakologický3401890078333731890013354102137229281332391417477539564613663718
ústav11151890013360103140193244
1.1382189001335774
LF14791890013352105
UK16071890013371130
a17611890013353
VFN,18371890013361115185208
Praha2069189001335893146206258
Psychiatrická340240001215393142187243267316349383407453500551
onemocnění9112400012154111163247303350406457514538
a14692400012148
delirantní15372400012156108132156190239295329385409
stavy1966240001214075124172223
léčené2209240001212475122172228280
psychofarmaky2509240001215797146191247303333383416501550598649
jsou3178240001212464121177
častou3375240001214594134169224280
komorbiditou367524000121471023402540012183140174232256314338372427483
u8462540012155
pacientů9242540012157107153176228284318373
s13202540012140
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ledvin.1921254001212375133182207263285
Ačkoliv22292540012161106153208233257306
je2558254001212476
zažitá2656254001214394138163197247
představa,2925254001215791142200240275325373422444
že3392254001214394
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psychofarmak340268001215797146191247303333383416501550598
je958268001212475
lipofilní1053268001212448105162192219243299323
povahy13962680012157114162212268314
a17302680012148
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se2139268001213991
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tak2768268001213382130
pro2918268001215791146
celou3084268001214595120176232
řadu3336268001213382140195
běžně35512680012157109153209261
podávaných3402820012157114172221269318375421466522
léčiv892282001212475122146195
to1117282001213388
neplatí12362820012155107165190239272296
a15622820012149
jejich1641282001212476100125171227
dávkování18982820012156105153201256304354410434
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u27522820012155
pacientů28372820012157107152176228284318373
s32412820012139
chronickým33102820012145101135190247271317365416501
onemocněním3402960012155112163248304350407458514539623
ledvin988296001212475133183208264
(CKD),1277296001212885139208235255
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akutním1804296001214896152186243267351
poškozením21802960012157114154202257299350407431516
ledvin2721296001212375133182207263
(AKI)3010296001212889144170198
upravit.32332960012156113147197244269303325
Předkládaný3584296001215385136194340310001214773122180229285331
článek695310001214569118174226274
se992310001214091
věnuje1107310001214898155210235286
vlivu141731000121487397146203
zhoršených1644310001214299155189230282338385430486
ledvinových2153310001212475134183208264320368420465521
funkcí2697310001213087143191235259
a29803100012148
extrakorporálních3052310001215098135168218265320354412469503553577633657703759
eliminačních340324001215176101187211269319365422447494551
metod9223240012185137172228288
na12413240012156106
renálně1378324001213385143193218275327
eliminovaná1737324001215076101186211268325375425482532
psychofarmaka,2300324001215899149195252310340391426512562611662684
především3015324001215893144204256306347372457
tiaprid,3503324001213459109167202227286308
amisulprid,3403380012148132157197252277334368393451473
sulpirid,843338001213995119177202235260317339
risperidon,121233800121335898155208241266324380437459
paliperidon,17013380012157107131155213265299323381437494516
venlafaxin,2247338001214898155180229259309357382438460
lithium273733800121244882138162218302
a30703380012148
další.31483380012157106130170194216
Rovněž33943380012154110158216267311
je3735338001212576
věnována340352001214796151206253301356404
pozornost7633520012156112153208241296351390424
vlivu120635200121477194143198
hypoproteinemie,14233520012154100157213269302357389438462517567650673723744
která2185352001214682131164213
se2416352001213990
rozvíjí2524352001213387129179203228251
u27943520012154
pacientů28673520012156105149172222278310365
s32503520012139
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syndromem340366001214089146204237293377429514
na8773660012155104
farmakokinetiku1004366001213080113198247295349398423480531565590637694
a17213660012148
bezpečnost17923660012157109153211263310366422462497
terapie2312366001213484118167225250301
valproátem.2636366001214898122179213269319352402487509
Klíčová340382001246291119165223275329
slova:696382001244372131183237263
akutní987383001214896151185241264
poškození12793830012158114153200255297347403427
ledvin,1734383001212475132181205261282
chronické20453830012145100133188244267312359408
poškození24823830012157113153200254296347403426
ledvin,2937383001212374132181205260281
hemodialýza,32473830012156107191246304327376399447493543564
antipsychotika,3403970012148103136159215255303347402457490513559609630
antidepresiva,9913970012148103136159215266323356405445468516565586
stabilizátory1598397001213973122179202226249291341374428461511
nálady.21303970012156104127175232279296
Altered340424001246693131184223277337
pharmacokinetics6984240012459119172210297350396454508538597650688716762807
of1525424001245792
selected1637424001244497126179226264318378
psychopharmaceuticals2036424001245910315720126031937943949253061667071676882886589493999310211065
in3121424001242787
patients32284240012460113150178232291328372
with3404380012476104141201
chronic5614380012445105143202261289334
kidney915438001245584144203257308
disease1243438001246088132185239283336
Psychiatric340456001215289136178232254300331362385428
illness78445600121234567120169207245
and10454560012147101155
delirious12164560012156104127149180203256309347
states1579456001213972119150198236
treated1831456001213263111158189237292
with2139456001217295127180
psychopharmaceuticals2335456001215694140183236289345399445476558604647695748780802845892914952
are3303456001214779127
common3446456001214496177258311365
comorbidities340470001214599182237270327351408431464487537576
in934470001212479
patients10314700012157106138161211267300340
with1389470001217497130186
renal1593470001213282138186209
impairment.18204700012124107163212235268351402458490511
Although2349470001216185118173228283339395
the2762470001213388138
conventional2918470001214599155201250306338361416472520543
wisdom3479470001217498137193248332
is340484001212362
that421484001213389137169
most6094840012183138178212
psychopharmaceuticals839484001215796145189244299356412460492576624669718773806829874923946985
are1843484001214881131
lipophilic1992484001212447103159217272296319342387
in2397484001212479
nature24954840012155103136191223273
and27874840012148103160
are2966484001214880130
not31154840012156111143
renally3277484001213383138186210233280
eliminated,3576484001215074971802043404980012155102134183239260
this617498001213387110148
is783498001212361
not8614980012155110142
true1020498001213365120169
for1207498001212983115
a13394980012148
number14044980012155109192248298330
of1751498001215583
commonly1852498001214497180262316371394441
administered23104980012148104186209263286324357406438487544
drugs,2871498001215688143198237257
and31454980012148103159
their3321498001213387137160192
dosing35304980012156110149171226281
needs3405120012155106157214253
to619512001213387
be7315120012157108
adjusted8645120012148105129183223257306363
in1252512001212479
patients13565120012157106138161211267299340
with1721512001217498131186
chronic19325120012145100132187243266310
kidney2268512001214771128183234280
disease2574512001215679118169217256306
(CKD)2906512001212884137205231
or3162512001215588
acute3275512001214893148181230
kidney3530512001214772129184234281
injury340526001212379102157189240
(AKI).602526001212989143168195213
The8385260012150106157
present1018526001215790139179229285317
article1358526001214881117140184208258
focuses1639526001212984130184224274314
on19755260012155111
the2109526001213388139
effect2270526001215180113163209244
of2537526001215584
impaired26445260012123106163212235267317374
renal3041526001213383139187210
function3274526001212985140185220243299354
and36515260012148104160
extracorporeal340540001215097133166214259313346403459492542590613
elimination98154000121507497180204259307339362417473
methods14825400012183134167223278335374
on18845400012155111
renally2023540001213383138186210233280
eliminated233154000121507497180204259307339389446
psychopharmaceuticals,28055400012157961441882432983554114594925766246697187738068298749239469851006
especially340554001215191148200246270318342366414
thiapride,783554001213389113161219252276334385405
amisulpride,12175540012148133156196251275333366390447498519
sulpiride,1765554001214095119176200233257314365386
risperidone,218055400121335796154205239263320376433484504
paliperidone,27135540012157107131154212264297321378434491542562
venlafaxine,3304554001214999155179228257307355379435486507
lithium34056800121244882138162218303
and6725680012149105163
others.864568001215690146198232273295
Attention1188568001216395131181238272295352409
is1626568001212464
also1719568001214973113169
given1918568001215680130180237
to2184568001213489
the2302568001213490142
effect2473568001215182115167213250
of2752568001215686
hypoproteinemia28675680012156103162219277311367401451475532583669693742
that3638568001213390139172
develops3405820012156107154203227283340379
in745582001212378
patients8495820012157105138161211267299340
with1214582001217498131186
nephrotic14255820012156106163219252306339362407
syndrome1858582001213987144200233287371422
on23055820012155111
the2441582001213489139
pharmacokinetics26065820012157113161193277325370423471495551601635658702743
and33755820012148103160
safety3560582001214089118168202252
of340596001215584
valproate445596001214897120177210264313345395
therapy.861596001213388139172220277323339
Key3406120012461113164
words:5266120012476133172232277303
acute852613001214893148181230
kidney1105613001214772129184234281
injury,1409613001212379102157189239255
chronic16876130012145100133187243266311
kidney2021613001214772128184234281
injury,2325613001212378101156189239255
hemodialysis,26036130012156106190245302325373397444484506545567
antipsychotics,31936130012148103135158215254302346401456489512557598619
antidepressants,3406270012148103136159215266323356406445484533588621661682
mood10446270012183138194251
stabilizers.1316627001214074123179203226249292342375415437
Psychiatrická480664001074578119159207225266293319339379417459
onemocnění957664001074896141214263304352396444463
jsou1437664001072052101149
běžnou1603664001075095132180229277
komorbiditou18986640010738853406780010774122149199218268286314361409
u7726780010748
pacientů842678001075092132151195243270317
s11826780010734
chronickým1238678001074189115162211229269307350425
onemocněním1685678001074897141215263304340692001074892140158231
ledvin588692001071963113154173221
(CKD)825692001072473117177199
a10406920010741
deprese1097692001074993143169212246290
a14036920010741
úzkost1461692001074784122169203232
jsou1709692001071952100148
nejčastějšími1874692001074892111340706001073979111139180198229247318336
psychiatrickými691706001074981121159205223262288314332371407449521539
poruchami1245706001074996122169208255294366383
u16437060010747
pacientů1706706001074888128145188234260306
s3407200010734
CKD,402720001075298159173
které602720001073971114142186
významně815720001074286127177219294344389
zhoršují1231720001073787137165200249269288
kvalitu1546720001073984127147166195244
jejich181872000107196484103145194
života34073400107365596144171213
(1).5727340010724648194
Rovněž686734001074594134183227264
delirium969734001074993113131157177224297
je1286734001071963
častou1368734001074182115144191239
komplikací1626734001073886160209229247285327368387
doprovázející340748001074895144170216255295331373391409447465
zhoršení821748001073583130156189232278296
klinického113374800107375774121139178214256303350
stavu,1499748001073361101140187202
zejména171674800107367795167210257296
pak340762001075091129
u4887620010748
hospitalizovaných555762001074997131180199227268287306342389430471519558597645
pacientů1220762001074991132150194242269317
vyššího1556762001074184118151169219267
věku1842762001074184122170
(2).3407760010723658699
Pacienti454776001074584123141184230256274
se744776001073376
schizofrenií835776001073373120137173219242269310357375393
jsou124377600107195198145
naopak1403776001074887134183223260
ve1679776001074082
vyšším1776776001074082115147165236
riziku214066400107274682102139188
vzniku2353664001074079128147184233
CKD2611664001075195155
(3,279166400107246681
4).289766400107446578
Roli3000664001074694114132
v31576640010741
patogenezi3223664001075091118165215259307351389408
CKD3656664001075195155
u21406780010748
těchto2205678001072870111159186233
pacientů2455678001074991132150194242269317
může27896780010774121158200
hrát3007678001074874116143
i31676780010719
fakt,3203678001072466104134151
že3371678001073679
na3467678001074889
rozvoji3573678001072774109153200220238
CKD2140692001075194153
se2309692001073376
často2401692001074080113141187
podílí2604692001074997146164184202
hypertenze2822692001074885135179205235277324360403
a32406920010741
diabetes3297692001074866106154198226267300
mellitus,361369200107731161351531712140706001072774106121
které2277706001073867109134176
spolu2469706001073381129148194
s26797060010733
obezitou2727706001074796140176195222268315
a30577060010740
dyslipidemií3113706001074887120138156204223271313386403421
mohou35507060010772120167214261
být2140720001075089120
důsledkem2282720001074997129148192242280323397
nežádoucích2701720001074892129172221269317358377417465
účinků3188720001074888106154192240
některých3450720001074993131161204230273313361
antipsychotik2140734001074189116135184218259298346395422441479
(5).263873400107246689102
Většina2280748001074791120157176226269
psychofarmak2577748001075186129171221271297341368445488528
je3133748001072066
lipofilní322774800107203991142167188208258278
povahy35337480010751102144188238278
a21407620010741
renálně2205762001072770118158177225269
se2499762001073377
neeliminují.2601762001074892137156174248266314362381399415
Existuje3040762001074283102135164212231275
však3339762001074175116154
řada3518762001072668117158
výjimek,37007620010741842140776001072039115160200219
pro2386776001075179128
které2541776001073971115143187
to2755776001072977
neplatí2860776001074995146166208236256
a31447760010741
jejich321377600107206585104146195
dávkování3436776001075092133173222263306356375
DECLARATIONS:4068241008648871301662142563043393604124625014570241008514
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Committee464831300854179139198215239265300337
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