933
PSYCHIATRIE341804001074588136186244265319357405427470
PRO833804001074591153
PRAXI1008804001074591148201221
/12758040010731
Psychiatr.1351804001074578119159207225266293320332
praxi.1703804001074976118158177193
2025;26(2):83-861916804001074386128172185229271295338360374418461489534579
/25408040010731
www.psychiatriepropraxi.cz46148040010765133201214264298339379427445485513539559602652679726776803845884904919960998
861828020012657116
PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
Léčba3413600106296196132172
farmakorezistentních52936001062866102156197232271307339374391424456489530562604622656697
stavů12423600106306399134175
–1433360010645
2.149336001063248
část:155636001063274108140152
Farmakorezistentní172336001062967102157197233272308340374392424457489530563604622
deprese236136001063769104139171206237
chických34062001074089110151191235276326
poruch.686620010749100128178220270287
Pokrok99362001074593133163211251
v1264620010741
této132562001072872101149
oblasti149462001074899121163197228248
přispěl17626200107507899133184230251
k340760010738
zavedení40076001073781122167219265315335
tzv.75776001072869114128
polygenního907760010750101122164215260310360380432482
rizikového14117600107274886108147196238283333384
skóre181776001073373122151195
(polygenic34090001072476127148190240286336357399
(risk)7599000107245071105145172
score,95190001073476125153198214
PGS),1186900010745103147172187
které139490001073871115143188
měří1602900010774120147168
genetické17919000107499514519134010400107284991131175
riziko54510400107274887108147197
na772104001074890
základě892104001073781121143186237283
běžných1205104001075096135186226268318
genetických1552104001074995146192221242284324369410460
variant340118001074186114136179230259
identifikovaných630118001071971118169199220246269309359402446497539581632
pomocí12931180010750102179231275296
celogenomových16201180010740861071582112583093613401320010774124166212253303
asociačních673132001074176126170190232275325345387437
studií.1140132001073364114165186206224
Je1394132001073177
vypočítáváno1501132001074186138190233253283326368411461511
jako340146001071961101150
vážená512146001074184123167217260
suma793146001073483158201
rizikových101514600107274886107147196238283325374
alel1411146001074162107128
u15611460010748
konkrétního1631146001073887137177207251281331352340160001074898
jedince.462160001071964116137186229273290
Z7751600010748
výzkumu846160001074186127167217292342
vyplývá,1211160001074186138159201247291308
že1542160001073781
psychické1646160001075085128170220240282322367
poruchy3401740010750101130181223273314
jsou684174001071954105155
vysoce869174001074186122172216260
polygenní11591740010750101123165216262312362383
a15721740010741
geneticky1643174001074995146192222242285325370
heterogenní340188001075098129176206257312360412464486
(29).862188001072571118144160
V10581880010748
recentně1141188001072875120166219249302350
publikované15271880010751104157180202244295339385437486
genetické340202001074995145191220241283323368
studii735202001073465115166186207
TRD970202001074190151
se1148202001073480
heritabilita1256202001074894122143173216268289309330359403
pohybovala16872020010749100151191243294214062001074186107151
v2322620010741
rozmezí239462001072777115193240280302
2–4,2272762001074591141158206
%,296462001076887
a3082620010741
bylo315462001075193115167
pozorováno3352620010750102141191220270314358409461
signifikantní214076001073454106156177203225265309360389439460
překrývání263076001075079124165195240287331381402
genetických306276001074996146192223243286326371413464
variant355676001074185113135177228256
s2140900010734
kognicí,220490001073887140190210253273290
hyperaktivní252590001074889141188217260301333354397448469
poruchou,3024900010750101130181223273324374392
schizofrenií,344690001073376126147185235261290335214010400107486989106
tendencí2270104001072872122173219269311332
k26251040010738
abúzu2687104001074192143181231
návykových2942104001074891133178218267309354396446
látek341110400107196291135175
a36101040010741
BMI36741040010746118139
(body2140118001072476127179221
mass23901180010774117152187
index)2607118001071968120165207233
(30).2869118001072468114138153
Sdílená3052118001074293114136182232275
biologie3356118001075071121142192244265310
má36961180010774116
potenciál21401320010751103133178230273294338359
vývoje2530132001074188135185207254
nových28151320010749101144190233284
farmakologických313013200107246998176220261311333384438459502543589631682
přístupů.214014600107507899134164214266315332
Závěr21401710014768131190251294
V22801880010746
celé2355188001074084105151
medicíně25351880010774120172192234255304350
se2914188001073480
snažíme3023188001073483126164185261307
o33591880010748
individualizovanou3436188001071968119140183204255304347214020200107193978127169213263314364
léčbu.2534202001071965108159210228
V27922020010746
psychiatrii2868202001075085128170220240283312341362382
vycházíme3280202001074186128178221260281357403
při3713202001075079100
volbě394062001074190111162209
léčby417662001071965108159200
ze440362001073681
znalosti451162001073687129150200235266287
současných482562001073384134176219254304344385435
možností5287620010774124162212262298394076001072849
psychofarmakoterapie,402076001075086129171222273299344372449492533583612657686730782803850866
pečlivé491776001075097141162182226272
anamnézy521976001074192135211262308348393
a3940900010740
zhodnocení399990001073685134184233282323366415435
psychického445290001074984125165214233274313356405454
stavu492590001073363104145194
včetně513890001074080123151200245
klinického540290001073759781261461873940104001073882132182
obrazu.4142104001074899128171210260277
Zatím4440104001074891120140215
nemáme4675104001074894169211286332
v50271040010740
běžné5087104001075096135185230
klinické533710400107386180130150192231276
praxi3940118001075078122163184
markery,41491180010774116144185230258303316
které4490118001073870115143188
by4702118001075091
nám4818118001074890166
v50081180010741
rozhodovacím5074118001072675112163213265315357400443463538
procesu3940132001075079129172217253303
pomohly.42731320010750102179230281302344358
Proto4662132001074573123152202
bychom4894132001075092134184235312
od52361320010749101
počátku536813200107501011451892183940146001073888
měli40511460010774120141161
usilovat4235146001074883103123173215259288
o45461460010748
optimalizaci4617146001074899129149225267288308346391433453
stávající5093146001073465108150193214234276296
léčby5412146001071965108159200
(využití3940160001072567114166206228260281
terapeutického4253160001072875104149202251302334356399441487539591
monitorování48761600010776128180202233283313364408453504526
léku,5433160001072068109161179
farmakogenetického394017400107246998176219260311364411462509539561604645691742793
testování4764174001072974110142192235279330351
metabolizujících51461740010775123153197250302324345385436394018800107194082102144194
enzymů)4164188001074494133178255304328
a45221880010741
včasné4593188001074182125161211257
stanovení4880188001073464108158208251296346367
farmakorezistence.5277188001072367961722152553043940202001072771110131166197241291333378394
LITERATURA341225001234978134189250318368438498567
1.34024200853648
McIntyre40324200835487102140161195217251
RS,6692420083356982
Alsuwaidan7662420083415682119171203219257290328
M,110824200835568
Baune119124200833568106144179
BT,13852420083356978
et147724200833457
al.15482420083324760
Treatment-resistant16232420083335084116138196231269290310332366340252008326416791124162184
depression:54425200833874113135169196223238276314327
definition,8912520083397491108146162184200238276289
prevalence,12012520083396095127160176211249281315327
detection,15492520083387396130162187202240279292
management,18612520083589012934026200833271106164199237258272
and62826200833270109
investigational7542620083155284118145168183222255276292330368400416
interventions.11862620083155375108129164198237258273311350376390
World159326200835793115131170
Psychiatry.17802620083356193125163178210340272008322437787
2023;22(3):394-412.44227200833569102136148183217235268286298333366402425461492522534
2.34028200853753
Henssler41528200834581121148176192228250
J,68628200832538
Kurschus7452820083367496125158197236264
M,103028200835670
Franklin11212820083345488128159176192231
J,137428200832437
et143228200833558
al.15122820083334962
Trajectories15962820083335185101137171196234257273309337
of195428200833959
acute34029200833264102124158
antidepressant5142920083327091106145180219241275302328362400421
efficacy:951292008334527088120153185218232
how119929200833776127
long13412920083155392131
to148729200832259
wait15622920083508398121
for16982920083195678
response?179229200832054811201591983403020083276389
A450302008342
systematic5143020083266088112147207240263279312
review8483020083215689106142195
and106430200833372112
meta-analysis119830200835995118152175209248282298331359374401
of162130200833858
long-term,17013020083155494134157181216238298311
placebo-controlled3403120083395588121155195235258293330369391413451467483518558
acute91931200833365104127161
treatment11013120083224479111133192228267289
trials.1411312008321435992108134148
J1580312008324
Clin16253120083415672110
Psychiatry.175631200833662961281661822142363403220083215565
2018;79:17r11470.42032200833468100131143176210223252282301333360391424457469
3.34033200853651
Habert41233200834477116151173197
J,63033200832436
Katzman6873320083346890121179212250
MA,95733200835597111
Oluboka108833200834763101140179210243
OJ,13523320083477082
et145433200833457
al.15313320083324760
Functional161233200833268106139163178216255287303
recovery19353320083215534034200833168100134156190
in54834200831452
major61834200835790105143165
depressive80134200833873112133167194221236268303
disorder:11213420083395480118140178213234248
focus13873420083185688126152
on155734200833776
early16513420083346687103134
optimized1803342008338779911517218734035200832862101
treatment.4543520083224377108130188222260282295
Prim7613520083355671129
Care9033520083397293127
Companion104335200833976134173206243258296334
CNS139035200834084116
Disord.15193520083456186124146184197
2016;18(5).172835200833468100131143173204222256274285
4.34036200853652
Kautzky41336200833569107130161192226
A,66036200834156
Dold73636200834685101141
M,89736200835569
Bartova9873620083356990115152185218
L,122636200833145
et129236200833457
al.13703620083324760
Clinical14513620083405671109125157190206
factors16773620083195385110147169196
predicting189436200833961953403720083395487112127166206
treatment5673720083224479111134193229268290
resistant878372008321558398125149182221243
depression:114237200833974114137171199226241280319332
affirmative1495372008332516987109168202224240273308
results18243720083215683121137160188
from3403820083194179138
the4993820083226196
European6163820083337092129170206238277
multicenter91438200835896111134150182216255277311333
study.12683820083265088128161171
Acta14603820083417398131
Psychiatr16123820083356295127166181214236258
Scand.189038200833366993403920083387790
2019;139(1):78-88.44539200833468100130143173203236256287302314347380403439474488
5.34040200853650
Silhan4104020083324762100132171
P,59940200833640
Urinovska6584020083446580118157189216245279
R,95640200833549
Kacirova102440200833569101116137174206239
I,128240200831528
et132940200833456
al.14044020083324760
What148340200835796128150
does165240200833876112139
antidepressant181040200833270911061451803404120083406398126154189229251
drug61441200833961101142
level7784120083165286122138
monitoring93941200835999139155179217240257296337
reveal12984120083225791127160176
about149741200833374114154178
outpatient169741200833978102143178201217253293316
treatment3404220083224581114137197234274296
and65942200833373114
patient7954220083407598114150190213
adherence?103142200833273113150172208247281316342
Pharmacopsychiatry.139642200833676109132192226260299340368402435475491524547570605616
2019;52(2):78-83.34043200833468100130143178211229263280292326359382418452464
6.34044200853651
Skaff4044420083326295114133
R.54944200833550
Tachyphylaxis6114420083326092129159199237267282314345360386
and101044200833169107
desensitization11304420083377298133170196211233248276309331346383421
depression.156444200833772111132165192218232270308321
CNS189744200834084116
Spectr.34045200833271107140164185195
2021;26(3):191-192.55145200833468101132141176209228262279291321351383402432463496508
7.34046200853645
Thase40446200833372104131166
ME.58846200835588101
Response7084620083367197136175214240275
to100246200832158
the10794620083226095
letter1193462008315507296130151
entitled13634620083347294109131147182221
„Tachyphylaxis16034620083205178111149179219258288304337368384410
and34047200833169107
desensitization4604720083387298133170196211233248276309331346383421
depression“89347200833873111132166192218233270308328
by123447200833869
Richard13154720083355182119151172210
Skaff.15374720083326295114133143
CNS169247200834084116
Spectr.182047200833271106138161182193
2021;26(3):193-194.34048200833468101133141176209228262279291321351384406436467502515
8.34049200853753
https://postupy-pece.psychiatrie.cz/specialni-psychiatrie/f3-depresivni-poruchy/deprese-u-dospelych/postup-v-4144920083386085126153166194215253293320344383423455478519555588623636676704737770808824857879901917953965998103010581083112311601193120912411257129613121334137514031436146815071523155615783405020083213671971161491712122472863083423693834164554704925325715936316637017327557918268658879219489831006104510671108114611731212124812631295132713651391142814671494151715551594161816511672
-lecbe-rezistentni-deprese.3405120083213772105144179203225259288304330353387425446485500522562597636658692719754766
9.34052200853548
Cipriani4015220083395492114129160197212
A,62552200834054
Furukawa6915220083326889126156188238270
TA,9735220083336983
Salanti10685220083326479111148169184
G,126452200834356
et133252200833456
al.14005220083314659
Comparative147152200833975133171203224256277292324358
efficacy184152200833351698711815034053200833164
and41753200833169108
acceptability5375320083326494128167188221260275290305327360
of91053200833756
2197953200833465
antidepressant10565320083327091106144179218239273299326358396417
drugs14865320083385997135161
for16605320083185577
the17495320083226094
acute185653200833263101123157
treatment3405420083224377109131189224262284
of63754200833857
adults70854200833171108123146174
with8955420083516689127
major103654200835790105143165
depressive121454200833873112134168195222236269303
disorder:15315420083385379118139177212233247
A1792542008341
systematic1847542008326588510914234055200835790111127159
review5125520083215587103137189
and71455200833270109
network8365520083377295148185207238
meta-analysis.108755200835792115147170202240272288320347361388401
Focus150155200833370103140167
(Am168155200831960118
Psychiatr181255200833561941251631783405620083325475
Publ).43056200833573112128147158
2018;16(4):420-429.60356200833469100131144174205224257274286320353387411448480514525
10.3405720085366984
Češková43757200834073100130167199232
E,68257200833245
Sedová74057200833267107145177209
M,96257200835568
Kellnerová1043572008335698499137172193230262295
R,135057200833650
Starobová14125720083335486108145184223255287
O.171257200834759
Once-a-178357200834786118151174207229
-day3405820083216193124
trazodone4775820083214376105142182220258293
in78358200831452
the8485820083226095
treatment9555820083224377109131189224262283
of125158200833756
depression132058200833873112134167194221235273312
in164558200831452
routine17105820083205795118133171206
clinical192958200833146613405920083385385117133
practice.4885920083396093126150165197231243
Pharmacology.74659200833573105126185217249286302340380412422
2018;102(3-4):206-212.118359200833468100131143173205238255289311347365376412446481505536567597610
11.3406020085376982
Nuñez44560200834685125162193
NA,66160200834689104
Joseph7896020083246593129170210
B,102360200833650
Pahwa109660200833670110162196
M,131660200835670
et141060200833558
al.14916020083335063
Augmentation157860200834281121182218258281315338354394434
strategies21402420083265071105127161201216251278
for24392420083195779
treatment25382420083224478110132191226265287
resistant2845242008321568398124148181219241
major310724200835890106144166
depression:329424200833873113135169196223238277316328
A3643242008341
systematic37052420083265986214025200832258118152176192226
review23922520083225892109145199
and261725200833373114
network27572520083397699155195218250
meta-analysis303325200835996120155179213253287303337366382409
J3469252008325
Affect35202520083426383119153179
Disord.37252520083476421402620083266486124137
2022;302:385-400.229326200833468101135148183217250263298332366388425461497510
12.21402720085366884
Ercis22392720083335485100126
M,238027200835467
Ozerdem246227200834777111132170205263
A,274027200834155
Singh28102720083324785124162
B.298627200833649
When305027200835796131169
and323427200833270109
how335727200833876127
to349927200832259
use35722720083386499
lithium3686272008315295290105214028200833795
augmentation225428200833270109166201240261294316331369407
for26802820083195678
treating27772820083224377109131146184223
major301928200835890105143165
depressive320328200833873112134168195221236269303
disorder.35252820083385380118139177212234244
J3788282008324
Clin21402920083405570108
Psychiatry.22632920083356294126164179211232254288298
2023;84(2):23ac14813.257629200833469101136148183219239273290302338372404437468499535567597609
13.21403020085366883
Vas22443020083366793
C,235830200834053
Jain24313020083245671109
A,256130200834155
Trivedi2636302008333506598132172187
M,284330200835568
et293230200833456
al.30083020083324760
Pharmacotherapy308930200833572105126184217249286308346381402435474505
for36153020083185677
treatment-resistant37133020083214377214031200833254112148186208227250284311326352375408447468
depression:262931200833873113134169196223237276314327
Antidepressants297631200834180101117156191230252287314340374412434461
and345831200833270110
atypical35883120083325488128144176209224
antipsychotics.21403220083327091107146172205236274313335350382410423
Psychiatr25773220083356194125163178210232253
Clin28443220083405570108
North296532200834583105130168
Am.314632200834199113
2023;327232200833468101136148
46(2):261-275.34333220083347089123141153188222252271302335367379
14.21403320085366984
Boku223733200833573104142
S,239233200833245
Nakagawa245033200834476106140178210261294
S,275633200833345
Toda281433200833367106138
H,296533200834457
Hishimoto30343320083445985123138195233255292
A.333933200834055
Neural340733200834479117138171186
basis36063320083387197112138
of375733200833756
major214034200835790105143164
depressive231734200833873112134168195221236269303
disorder:26333420083385379117139177212233247
beyond289334200833874105143181220
monoamine312634200835796134172205263278316351
hypothesis.349034200833768108147168206241268283309323
Psychiatry21403520083356194125163178210232254288
Clin24433520083405570108
Neurosci.256635200834580118139176203235250263
2018;72:3-12.284435200833569101132144177211223259281311341354
15.21403620085366883
McIntyre224136200835487102140161195217251
RS,25103620083356982
Rosenblat260936200833674101136174213229261283
JD,29103620083247081
Nemeroff300836200834580138173194231251270
CB,32963620083407588
et340236200833456
al.34763620083314760
Synthesizing35533620083336310112316119622323821403720083284380118
the22713720083215892
evidence23763720083336580118152190221254
for26423720083185576
ketamine27303720083306385117174188225260
and300237200833168107
esketamine31213720083336089122144176233247284319
in345237200831452
treatment-35163720083214275106128185219256277296
-resistant21403820083214479106122148172206245267
depression:242838200833974115137172199227242281320333
An278238200834181
international28843820083155376110132172205227243282321354370
expert327538200833567107144166191
opinion34873820083387995133149188227
on373538200833878
the21403920083226095
available22513920083316396111126159198214248
evidence25153920083346782121156194226260
and279139200833270109
implementation.291639200831472111127162220255293314347369384422461474
Am340639200834199
J3521392008324
Psychiatry.3561392008335619412516317821023221404020083215565
2021;178(5):383-399.222040200833468101133141171200234253286305317352386420442474508543554
16.21404120085367086
Wilkinson22474120083587590121137176203242281
ST,25494120083326777
Palamar26464120083366884117176209230
JJ,28974120083254961
Sanacora297941200833367105138171208230264
G.326441200834458
The334341200833373109
rapidly34734120083215494110149165197
shifting3691412008327658110021404220083223775114
ketamine22744220083306486119177192230265
landscape25594220083154785124151183216255291
in287042200831553
the29434220083226095
US.30584220083447689
JAMA316742200832464120162
Psychiatry.33494220083356294126164179211233254288298
2024;366742200833569102133145
81(3):221-222.21404320083346681115132144179214245264295329364377
17.21404420085366876
Kopeček223144200833572112148180214244
M,249044200835468
Andrashko257344200834179118139172198236266304
V,289244200833544
Renka295144200833570109139172
J.313844200832437
Průlomová31904420083355594109147205243275308
a3513442008332
udržovací35604420083377697128165197230214045200833146
léčba22004520083154982121154
rezistentní2368452008320548499126149182221242280295
depresivní267745200833873112134168195209242281296
poruchy29864520083397899138170208238
racemický32384520083215486119177193224255273273
m3528452008357
ketaminem35994520083296386118176191214046200833873130
–2286462008335
kazuistická23364620083306393131146172195211243273306
studie.26584620083264987126141176188
Psychiatrie.28614620083356294126164179211232254269304316
2024;(1):16-19.319346200833468101133144163195210221251282306337367378
18.21404720085366985
Fava22434720083326293126
M,238747200835568
Stahl24734720083325486124140
S,263147200833245
Pani269447200833567105120
L,283247200833145
et289547200833456
al.29694720083324760
REL-1017304747200833569100115146178209239
(Esmethadone)33044720083185179136171194232264303341380415432
as375447200833258
adjunctive21404820083327186124162194218233266300
treatment24604820083214377109130188223262283
in276248200831553
patients28344820083397294109144182203231
with30844820083516789127
major323148200835789105143164
depressive341548200833873112133168194221236268303
disorder:37374820083385321404920083266486124158179193
A2346492008341
phase240049200833877109135170
22583492008334
a2630492008331
randomized26744920083215492131169227242271305344
double-blind303149200833876114153169203226266282297334373
trial.3417492008322435990106119
Am354849200834199
J3660492008324
Psychiatry.3697492008335619321405020083316984116138159193203
2022;179(2):122-131.235950200833468101136148178208241260294312324354384418439469499530540
19.21405120085366983
Muzyk224351200835593122157188
A,245151200834156
Syed25275120083336397137
FZ,26855120083327084
Zhou278951200833876115153
H,296351200834457
et304051200833557
al.31185120083324760
Real-world319951200833570103118140192230252268307
treatment35275120083224378110132190225264285
patterns21405220083397293118151173211238
of239352200833756
patients24655220083387193108143181203230
In271152200831452
patients27795220083387193108143181203230
with30255220083506688126
major316752200835789105143164
depression,334752200833873112133167194221236274312325
dextromethorphan-bupropion36875220083387310521405320083224380139174196234272294334372404442465505543582604641681696734772
(AXS-05)292553200831960101134157194228246
significantly31845320083264180118133151168200233271292308339
improved353653200831573112133171203237276
depressive214054200833771109130162188214228259292
symptoms244454200832657114152173209265291
compared274654200833166123161193213246284
with30425420083496485122
bupropion317654200833875113133169208222259296
and348454200833168105
was360154200835081107
generally37195420083387121405520083377293125140155186
well23395520083508499114
tolerated.24655520083225874108129161183216255268
with27455520083506688125
major288355200835789104141162
depressive305855200833872111132165192218232265298
disorder33695520083385278116137175209230
treated36115520083224376108129162201
with21405620083516689127
auvelity®228056200833269102136152167189223253
in254656200831552
the26115620083226095
United27195620083448297119153193
States.29255620083325386108141168182
J3120562008324
Med315756200835590129
Econ.329956200833364101139153
2024;23:1-12.346556200833468101133145180214226255274305335347
20.21405720085377490
Du225257200834686
Y,236057200833645
Dou242757200834686126
Y,257457200833645
Wang264157200835991131171
M,283457200835670
et292657200833558
al.30055720083334963
Efficacy3090572008333527088122156189224
and333657200833272112
acceptability34705720083336698133174197231272288304320214058200832256
of221758200833858
anti-inflammatory22965820083327193109131148186204222254313372405427465487522
agents283958200833272107146168197
in305758200831553
major313158200835891107146168
depressive332058200833974114136171198226241274309
disorder:3650582008339548112014221405920083387395108
a2269592008332
systematic23215920083275986110144202234256271304
review26455920083215587103138189
and285559200833270109
meta-analysis.298559200835793115148170203241273289321348363389403
Front34085920083335390129150
Psychiatry.357959200833562941261641792112140602008322437787
2024;15:1407529.224260200833569102133145175205216246277313346379412446457
21.39402420085367082
Kappelmann403724200833568108147183198256288326364
N,441624200834558
Lewis448924200833165116132158
G,466224200834457
Dantzer473424200834577115137168202223
R,497224200833549
et503624200833456
al.51072420083324760
Antidepressant518224200834179101116155190229250284311338371409431
activity39402520083326488103136152174208
of416225200833857
anti-cytokine42342520083316991106128162196220257288304342377
treatment:46262520083214377109131189224262283297
a4938252008331
systematic49842520083265986109142200233254270302
review53002520083215587103138189
and550425200833169108
meta-analysis394026200835792115147170202240273288320347362388
of434526200833757
clinical4419262008331466199114146179195
trials4631262008322435991106132
of478026200833857
chronic48542620083316991128166181213
inflammatory5085262008314527087119177234267289325347381
conditions.5483262008332691073940272008338537691129167194207
Mol416327200835492108
Psychiatry.42872720083356194125163178210232253287297
2018;23(2):335-343.460027200833468100131143178213231265283295330363396418450486518531
22.39402820085367288
Češková404128200834073100130167199232
E.428628200833245
Kombinace434428200833572130170185223255287321
antidepresiv46772820083327091107145180219241275301316348
v5038282008332
léčbě50832820083154982121156
deprese:525228200833872112133167194229241
Doporučení55062820083458439402920083397799137169203241256
a4211292008332
klinická4259292008329466199114146176209
praxe.44832920083396194125159171
Čes467029200834073100
a4786292008331
slov48332920083264179111
Psychiat.49592920083366294126164179211233246
2015;11:33-36.522029200833469100130141171199207243276297330364378
23.39403020085357185
Henssler403830200834378115140166181215235
J,428630200832335
Alexander43333020083405589120152189227261282
D,462730200834555
Schwarzer469430200833264101150182203232266286
G,499230200834356
et506030200833455
al.51283020083314658
Combining519830200834076133171186223238275313
antidepressants55233020083316839403120083223776110149171205232258291329351378
vs433131200833259
antidepressant44033120083316991106145179218240274301327360398420
monotherapy483631200835795133172193231266287320359391
for52403120083185577
treatment53303120083214377109130188223261283
of394032200833757
patients40133220083397294109144182203231
with42613220083516689127
acute440532200833264102124158
depression:458032200833873112134168194221236274312324
A4921322008341
systematic49793220083265986109143201233255270302
review52983220083215587103138189
and550432200833169108
meta-analysis.394033200835792115147170202240273288320347362388401
JAMA435733200832464119161
Psychiatry.45343320083356193125163178210232253287297
2022;79(4):300-312.484733200833468101135148181214233266283295331365401425457488518531
24.39403420085367187
Carhart-Harris40473420083407394133166187212232278310332354369396
RL,44633420083366882
Bolstridge45663420083357490116139161177216255290
M,487734200835468
Rucker496634200833573105136170191
J,517834200832436
et523534200833457
al.53123420083324861
Psilocybin539334200833662779213116419739403520083395492
with40513520083516689127
psychological41973520083396698130168206222260300315347380395
support461135200832664103142181203227
for48583520083185677
treatment-resistant49543520083224478109131189224262284304326360387401428451483522543
depression:55163520083387339403620083396094121148163201239251
an421036200833270
open-label430036200833776112150172189221260296311
feasibility46313620083185384111126165180196211233267
study.49173620083264987126158168
Lancet510536200833164102135168191
Psychiatry.53153620083356194125163178210232253288298
2016;3(7):619-627.394037200833468100131143178197231251263298328359382419453486492
25.39403820085367287
Goodwin404738200834482121161212228266
GM,433238200834499112
Aaronson44643820083417495132171197235274
ST,47583820083326775
Alvarez48533820083415789122143177207
O,508038200834758
et515838200833456
al.52343820083314760
Single-dose53143820083324785124139174197237275394039200832763
psilocybin40253920083406884100140174209251267307
for43543920083195881
a4457392008332
treatment-resistant45113920083234581114137197234274296317340376404420447471506545568
episode51013920083357692120160201237
of536039200833959
major544139200835993109149172
depression:394040200833974114136171198225240279318330
impact429140200831574114147180205
on451640200833877
patient-reported46144020083397395111146185207227249284324363385411445485
depression512040200833974114136171198225240279318
severity,545940200832662951303940412008321386196107
anxiety,406841200833372105121157180215226
function,43154120083195999132157173213253266
and460341200833272112
quality473741200833978112128144167202
of496141200833858
life.5041412008315315187100
J5162412008325
Affect52094120083426281117151176
Disord.54074120083466390130152192206
2023;327:120-127.394042200833468101136147182215248258288318352376406436469475
26.39404320085367187
Sarris40454320083326587108124150
J,421343200832436
Ravindran426743200833669100116154193214247285
A,457043200834155
Yatham46434320083366587125157215
LN,48764320083327790
et498443200833456
al.50584320083324760
Clinician51364320083405670108123155171202241
guidelines5395432008338759012916418019539404420083377299
for40514420083195677
the41414420083226094
treatment42484420083224377108130188222260281
of454244200833756
psychiatric46114420083396597129166181213235256271303
disorders49274420083385378116138176210231258
with51984420083506688126
nutraceuticals5337442008337749711815118221625339404520083223769102117143
and409745200833270109
phytoceuticals:421945200833978108133170203236274297312344377392418431
The466345200833372107
World478445200835794115131170
Federation496845200833266106140162195216232270308
of529045200833756
Societies536045200833371104119153176191226252
of394046200833757
Biological40144620083355088104142182197229262277
Psychiatry43084620083356294126164179211232254288
(WFSBP)461346200831978112144179214232
and486246200833270109
Canadian498846200834073111143182198230268
Network527346200834479102155192214245
for55354620083185677
Mood394047200835493132171
and412547200833270109
Anxiety424747200834179111126161183217
Treatments44784720083324983115137195230268290318
(CANMAT)480947200831958101146201243272294
Taskforce.51164720083336187117139176198229263275
World540447200835894116132171
J5588472008324
Biol39404820083355189105
Psychiatry.40604820083356194125163178210232253288298
2022;23(6):424-455.437348200833468101136148183218236269287299334366398421458490523535
27.39404920085367180
Miyaoka403549200835470102135173204237
T,428749200833342
Kanayama434449200833468106138169202260292
M,465149200835568
Wake473449200835889119153
R,490249200833650
et496749200833456
al.50384920083324760
Clostridium51134920083405593120143165180219234272330
butyricum5458492008338779913339405020083213668106164
MIYAIRI412050200835570106143158194210
588434650200833468104
as446650200833258
Adjunctive45415020083417994132170202226241274308
Therapy486550200833372107129162201232
for51135020083195678
Treatment-Resistant520750200833350841161381962312692903103473823940512008326406689121158179
Major413251200835486101138159
Depressive430451200834580118139173199225240272305
Disorder:46225120083456086123144182216237250
A4885512008341
Prospective49385120083355592118156191223247262294328
Open-Label527851200834786121158180213246284319335
Trial.3940522008333506597113126
Clin40815220083405570108
Neuropharmacol.420452200834580118139176216254287308366398431468483496
2018;41(5):151-155.471652200833468100131143178208223257275287317347378396427457490502
28.39405320085367288
https://www.cinp.org/nomenclature4043532008338598312315016218920926031436737841042546350251455257461263867571377180684587789292494698410051039
29.39405420085367185
Scott403754200833264101122146
K,419654200833449
Alda42585420083405594126
M.439654200835468
Integrating44775420083155273107146167199221236273312
polygenic48015420083397793124162197234249281
scores50945420083265895116150176
and528354200833169107
phenotypic54035420083387711114918739405520083225595110142
data40945520083387092124
to423155200832158
understand430155200833775114148169196219252289328
psychiatric46425520083386597128166181212234255270302
outcomes.49575520083377497127164222256283296
Am526655200834198
J5377552008324
Psychiatry.5414552008334609312416217639405620083325475109119
2024;181(7):572-574.407456200833569101133145175206238253288307319355388422443477510540553
30.39405720085377694
Kang406557200833672113155
J,425257200832539
Castro432357200834177106132156196
VM,455157200833695111
Ripperger46935720083375597139178201242280304
M,502957200835672
et513257200833560
al.52245720083335065
Genome-532157200834583125166228266291
-wide39405820083217591132168
association41315820083326088128162178212235251291331
study44845820083275191131165
of467158200833859
treatment-resistant47525820083224580114137197233273296317340375404420447472506545568
depression:53435820083387511613817420223024639405920083377689
Shared404859200833271104126161201
biology42685920083385593110149189222
with45085920083516790129
metabolic465659200835793116150190229246261294
traits.4969592008321447793116145159
Am514759200834199
J5265592008324
Psychiatry.53085920083356295127166182215237259294305
2024;181(7):608-619.394060200833469103135148178210243259294314327363399435459496527558570