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pseudorezistence.3277254001215696146202259314347397441465504340268001213381136181230250
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a3402820012148
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je1909282001212576
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zmíněna22912820012143127151208259316365
perspektivní26792820012157109143184242294342379403452509533
léčba.3236282001212375121179228251
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psychiatrie.2933313001215796144188243266314346379403453473
Treatment340340001245587141194231319372432468
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states1811340001244380134171224269
in2100340001242786
psychiatry22063400012460104158202261289342379419474
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1:2978340001245577
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substances3202400001213994151190224273328373422461
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briefly340414001215790113164193220267
mentioned.6284140012184134190222245300356407464485
Key3404300012461113164
words:5274300012476133172232276302
treatment-resistant853431001213366115163196279330385418446480529569592631665713769801
schizophrenia,1678431001213984139163205260317373406455511534582603
pseudoresistance,2305431001215696146201258313346396435458497531580635680729749
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antipsychotics,34794310012148103135158215254303340445001214498152185207251291311
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augmentation,10984450012148101156238288343374422454476530585605
combination1720445001214597180236259313360392414468523
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psychiatry.3375445001215695142185239262309340372422437
Úvod3404930014780142208279
Závažné480510001074887125164199246288
psychické781510001074981120157203220258294335
poruchy1129510001074996121167206252288
(v1431510001072360
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SMI,6055240010741108125139
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mental9945240010773115161186226243
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zahrnují1563524001073677123148194240257274
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mírou837552001077492117163210
farmakorezistence,106755200107246590164204241287313355392410442470511559598640653
která1740552001073868110135176
se1936552001073376
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poruchy,1601566001074996122169208254291302
do1917566001074995
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%4395800010765
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poruch578580001074995120166205250
schizofrenního842580001073371117133168213235260301347392409457503
spektra1358580001073380122158187212251
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Jejich109262200107317491108147193
léčba1299622001071961100148188
není1501622001074890136153
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často340636001074081113141187
jde546636001071967110
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léčených916636001071962103144191229268315
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proces1776636001075076122162204237
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je932650001071961
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správná1327650001073380105144182229268
léčba.1608650001071961100147187202
Vývoj1823650001074584127172189
nových340664001074997137180220268
léků633664001071963101149
je807664001072064
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a3406780010741
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k13606780010738
tomu1416678001072773146193
se1627678001073377
snažíme1722678001073380120156174247290
maximálně3406920010774114152171243283301348391
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stávajících979692001073462102141182200217256274313360
možností.13576920010774122156204252284312330345
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farmakorezistentní7967170014739100143246307369435479541596627677721782852894962993
schizofrenie3407310014750105174205259327366410472542572635
V4807480010746
české549748001074082116153196
odborné768748001074898148197224273317
literatuře110874800107193866108135176203251278320
se1451748001073478
běžně1552748001075094131180224
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o4137620010749
farmakorezistentní48876200107246794169210249297324368406426459488531580608657676
schizofrenii,1190762001073476124143180228253281324373392411427
v16447620010741
anglicky1712762001074190140159178219257301
psané340776001074981122169212
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pojem1248776001074996115157229
„na1493776001072673113
léčbu1621776001071962102150197
rezistentní18337760010726681041221542140496001072870118145193212
schizofrenie“2368496001073474122141177224248276319367385429455
(treatment-resistant284049600107245076119159186260304352379403431474507525558587628676703
schizophrenia,35594960010734751221411772242140510001075098125168216234275290
TRS),2447510001074289131155169
kterou2632510001073869112138185233
v28825100010741
dalším2940510001074989108141159232
textu3189510001072870110141189
používáme.3394510001075099147184203244286359404418
Meltzer21405240010770115135163202245272
v24395240010740
r.2506524001072739
19972572524001074482127169
ve2767524001074185
své2878524001073477120
publikaci3025524001075098148168187225268308327
o33795240010748
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TRS3680524001074289132
klozapinem2140538001073858106141183232251298342415
označil2572538001074782131171211229248
za2836538001073678
pacienty2930538001075091131150193241267310
s32565380010733
TRS3306538001074188130
nemocné,3452538001074892165213254302346360
u21405520010748
kterých2214552001073869112138182221270
přes2510552001075076119153
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dvěma2140566001075094139216259
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se3365566001073481
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včetně2140594001074180122150198242
dezorganizace,2399594001074993130177203251292340358395437478520534
nebo2950594001074892142191
negativní3157594001074993143183210229270319337
příznaky351159400107497695132180221259302
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se2498608001073479
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20192339636001074487127165
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223606500010744
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(AP)2982650001072476122144
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dávce3600650001074990130170213
(≥2140664001072474
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mg23776640010773122
chlorpromazinového2515664001073987105152179228255301374414450469516564603646693741
ekvivalentu)3272664001074380123142183223242285332359406427
po3715664001074997
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dobu2506678001074997146195
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s33356780010733
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hodnocením2140692001074897147195243285327375394468
adherence2634692001074190138182209252300341383
(3).304469200107236687100
Podobná3170692001074692142191241289330
definice3526692001074994117137185204244286
je2140706001071963
i22307060010719
v22757060010741
novějších2343706001074897137181200232251291340
mezinárodních27097060010774119156176224265291339389437456496545
doporučených3280706001074998148198225274314357405444484532
postupech,2140720001075099132161209259304345393409
navíc2565720001074989129148188
je2770720001072063
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akceptováno,3335720001074179118161210238285325366415463478
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jedno2237734001071963113161209
z24647340010736
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AP2936734001075297
by3051734001075089
mělo31587340010773117137185
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AP3498734001075398
2.3613734001074460
generace36907340010749932140748001074892118159200242
(AP2G).2398748001072475120162217240253
Měla26677480010770113132172
by2855748001075089
být2960748001074988119
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adherence,3418748001074089137181207250297338380394
pokud2140762001075099137186235
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krevních3262762001073866109149198217257305
hladin3589762001074867107157175223
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hladin3397776001075070112163183233
léku3657776001072066105155
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