992
www.psychiatriepropraxi.cz3408043010765133201214264298339379427445485513539559602652679726776803845884904919960998
/33238043010732
Psychiatr.3400804301074578119158206225265292319331
praxi.3751804301075077118158177193
2024;25(3):158-1653964804301074487128168183227271293335356371408446489517556595638
/46478043010731
PSYCHIATRIE4724804301074589136186244265319357405427470
PRO5216804301074591154
PRAXI5391804301074591148201221
16556558026012657111168
ZAZNĚLO4447207012659130193267325382456
NA4925207012670140
KONGRESE5087207012665138211284349408467525
Na418436501063979
cestě42793650106326498131163
k4458365010633
personalizované450736501063364100134175217257288305338377414451492524
léčbě50463650106296296132165
schizofrenie522636501063166107124157196227263295336354385
né34062301074892
hmotnosti448623010748121169195243291324353371
a836623010740
následně89362301074788120139182232279323
došlo123262301074997130148196
k1444623010738
jejímu1498623010719638199172219
poklesu173362301075098136157200233280
o340763010747
6,540376301074459103
kg,52176301073785100
snížila6377630107338098134153171211
se86476301073477
glykemie95776301074967106144187259278321
(o129476301072368
0,6137876301074458103
mmol/l),1495763010773146194213245264288301
hladina18127630107486710615517334090301074889
LDL44990301074199140
cholesterolu60990301074088137156200234263306332379399446
(o107690301072369
1,3116590301074455100
mmol/l),1280903010774147196216248268292306
triglyceridů16069030107285574123142182222264291310359406
(o340104301072469
1,342810430107445499
mmol/l)5431043010773147196215247268292
a8531043010741
prolaktinu913104301075077124143184222253271319367
(o1298104301072470
641386104301074491
mIU/l).1495104301077493149178198222236
Pacient1749104301074586126145188237263
byl340118301075090111
celkově477118301074184104142190231275
živější,77911830107365698141160194212228
sám1034118301073477151
referoval121211830107277095139166214255297316
znovunabytí1555118301073786135176226275316366406438457
schopnosti340132301073477126176228279329364394414
naplno781132301075092143164213264
prožívat1072132301075179128165185228271299
emoce.13991323010745121171214258273
Zkřížená1700132301075089118138176220270312
titrace34014630107284674101142183225
byla581146301075089109149
u7461463010748
tohoto810146301072875123171198245
nemocného1071146301074892165214255303347395443
velmi1530146301074184103176194
pomalá1741146301074998172212231272
a3401603010741
opatrná402160301074898140167193242283
z7061603010736
důvodu763160301074997138185235283
převádění1067160301074976119160201251294342361
v14491603010741
ambulantních15111603010741114164212231272320346395413453501
podmínkách,340174301074997147219237284321363403450465
závažnosti821174301073677116157193241289322350368
epizody1205174301074392111147193242281
i15021743010719
relativně153717430107266887127153172212260303
krátké1856174301073865106132340188301073983
doby450188301074999150190
od6671883010749100
propuštění794188301075178126178227261290334383402
z12231883010737
nemocnice.1287188301074994169219261310329370414429
Pacient1743188301074687129148193242269
je214062301071963
nyní222862301074887136154
již24076230107203875
32506623010744
roky257562301072774113155
ve275562301074184
funkční286462301072473121159198246264
remisi,315362301072770143162195213228
dostudoval340662301074997131160208257306346387406
vysokou214076301074184118166205252300
školu246076301073471119138186
a2665763010741
pracuje.272676301075077118159207225269284
Závěr21401015014365120173230265
Schizofrenie2280118301074182130149186234258286330378397441
postihuje2739118301074998132162181229277297341
na3098118301074788
celém3204118301074082102147220
světě3442118301073375118147189
okolo36491183010747861342140132301071969
242238132301074486
milionů2353132301077494115135185235284
lidí.266713230107193990110128
U28241323010756
902909132301074491
%30291323010767
z31251323010736
nich3190132301074969111161
se3380132301073480
při348913230107497899
první3617132301075078124175195
epizodě2140146301074495116154203255301
objeví2466146301074799120166208230
nejméně2720146301074994115190236286332
130771463010744
negativní3145146301074995146189218238281332352
příznak.352214630107507899138188231271290
V21401603010746
léčbě2214160301071965108159206
jsou2448160301072054104154
doporučována2631160301074999151202230281323371413456506549
preferenčně3208160301075079124149194223267317360409455
antipsychotika36921603010741902140174301072848100135178219269319348369409453
2.2621174301074461
generace,2711174301074995145191219262305349365
která3105174301073871115143187
ale3320174301074162108
mají34561743010774117137158
řadu3642174301072770121171
nežádoucích2140188301074895134178229279330372393435485
účinků.2655188301074790110160200250267
Častý2952188301075195130161205
je3187188301072066
vznik3283188301074081132152192
diabetu,3505188301074970112164211240290308
nárůst394062301074789116165198228
tělesné41876230107277090135169218262
hmotnosti,4468623010748121170198247296331360380396
hypertenze488362301074887138184211243286334372416
a5317623010741
hyperprolaktinemie.537762301074786137183210394076301074977125146188227259279328373447467512528
K4488763010744
dispozici455176301074969103153203239260301321
máme4891763010773115189235
i5145763010719
moderní5183763010773123174219246296316
léky,55187630107196439409030107388295
jako405590301071961101149
je422490301071964
kariprazin,430890301073882110131181210253292312362379
který470790301073770114142186
má4913903010773116
vysokou504890301074186121171211259309
afinitu53779030107406687136156186235
k39401043010738
D340011043010758101
receptorům,4124104301072771114159210239288317367442459
dlouhý4606104301074970120170219260
biologický4888104301075071121142192244265307346391
poločas,53021043010749100122172215258293311
vykazuje3940118301074187128173213264285332
parciální4303118301075094123165185228250300321
agonismus4654118301074294145196217252329379414
k50991183010739
serotoninovým51681183010734811101601892392903113624133940132301074084158
a41171323010740
dopaminergním4176132301074897147189263282330375402451499518592
receptorům,4787132301072669111154204232279307355429445
minimální5251132301077292140160233274294342361
metabolické39401463010774120149193244295316337379418463
a44321463010740
endokrinní4501146301074494145195235265286336386406
nežádoucí4935146301074995133177228279329371391
účinky,5355146301074890110160199244257
má39401603010774116
prokázanou4086160301075079128168212251295345396446
účinnost4562160301074790110160209260295326
v49181603010740
prevenci4988160301075079124166211261304324
relapsů534216030107267192135186222270
a39401743010742
efektivně4017174301074572119161196218263316364
zmírňuje44161743010737116138168221272294342
negativní4793174301074997152196227249294347369
symptomy5196174301073580160213244295374416
schizofrenie.3940188301073476126146185233259289334383404449466
LITERATURA341212001234978134189250318368438498567
1.34022800853648
McCutcheon40422810835487128165187218256291329368
RA,7882281083357892
Reis8962281083357085111
Marques102322810835487108146184219246
T,128422810833342
Howes134122810834483134168195
OD.155222810834793104
Schizophrenia1672228108332651031181471842242622833173402381083375283
-436238108320
An46923810834078
Overview.55923810834780114134169184218269279
JAMA85023810832464119160
Psychiatry.10222381083356193124161176207229250283293
2020132723810833468100134
Feb147323810833265104
1;77(2):201–210.15902381083334174108124157174186221254285318349380411423
2.34024800853652
Carbon4132481083407395135174213
M,64624810835569
Correll7362481083407799121155171186
CU.9432481083408596
Clinical10602481083405571109124156190205
predictors12862481083396195135150183207244266294
of160024810833857
therapeutic16782481083226096117150190226264287302335
response3402581083215582120159198224259
to61425810832259
antipsychotics6882581083316991106145172205236274312334350382409
in111225810831553
schizophrenia.11802581083265896111140177217256277311349364396409
Dialogues16042581083456193108147186224259285
Clin19042581083405570108
Neurosci.34026820834580117139176203235250263
201461826820833469100131
Dec;16(4):505–524.76526820834580113126156187206239257269304338372408442475507520
3.34027800853651
Leucht40827820833166103135173195
S,62027820833245
Leucht68227820833166103135173195
C,89427820834053
Huhn96427820834481119157
M,113827820835568
et122327820833456
al.12962782083324760
Sixty13732782083334779103137
Years15262782083366799120147
of169027820833756
Placebo-17632782083365082115148188226250
-Controlled34028820832164101139161182219235250285325
Antipsychotic68428820834179100116155182214246284322344359391
Drug109428820834567105144
Trials1257288208333506698113139
in141528820831552
Acute148628820834173111133167
Schizophrenia:167228820833265103118147184224262283317340298108338538597
Systematic4582981083326289112146204237259274306
Review,78429810833671103119154205216
Bayesian102029810833669100134161176208246
Meta-Analysis,128729810835489112145167209247279295327354369395408
and171529810833270110
Meta-184529810835590112145167
-Regression3403081083215893133154188215241256294332
of68730810833756
Efficacy757308108333516886118151183217
Predictors.9883081083355690129145177201238259286300
Am130230810834199
J1415308108324
Psychiatry.14533081083366294126164179211233254288298
2017176530810833468100130
Oct190930810834779103
1;174(10):927–942.3403182083344273102132152183215233245280314346379414449482494
4.34032800853550
Huhn40332810834380118155
M,57032810835467
Nikolakopoulou6493281083445888124140171201237276314351366403441
A,110232810834054
Schneider-Thoma116832810833263101138172187225259279298328366404461492
J,167332810832335
et172032810833455
al.17873281083324759
Comparative1858328108340761333403381083397192125147162194228
efficacy581338108334527088120152184218
and81133810833270109
tolerability9323381083225975109130163202217233247270303
of124833810833756
32131733810833466
oral13963381083375992107
antipsychotics15163381083316991106145171203235273311332347379407
for19363381083185577
the3403481083215993
acute4453481083316299121154
treatment6113481083224276107128185219256277
of90034810833755
adults96734810833270106121143170
with11493481083506587124
multi-episode128534810835693108130144166201240254280317356390
schizophrenia:16873481083265794109137173212250270303340358108338538597
a451358108332
systematic4983581083265885108142200232254269301
review8143581083215587103137188
and101735810833270109
network11403581083387395148186207238
meta-analysis.139335810835792114147169202240272287319346361387401
Lancet.180835810833265103135169191205
201934036820833468100130
Sep48636820833267106
14;394(10202):939–951.6083682083346577112145181200232263296330363381393428461494532566601632641
5.34037800853549
Schneider-Thoma40137810833263100137171186223257278297326364401458489
J,90237810832436
Chalkou95037810833976107122151187224
K,118637810833448
Dörries124637810834582103124139173199
C,145737810833951
et152037810833455
al.15873781083314658
Comparative165737810833975132170202223255276290322355
efficacy340388108334527087119152183217
and56938810833270108
tolerability6903881083215874108129162201216231246268301
of100438810833756
32107338810833366
oral11513881083375991106
and127038810833269108
long-acting13913881083145290129151183215239254291330
injectable17333881083155267102134158190229245279
antipsychotics3403981083326991106145171203235272310332347379406
for7593981083185677
the8493981083215994
maintenance95639810835789104142163196234266304336369
treatment13383981083224377108130188222260282
of163239810833857
adults170139810833271108123145173
with18873981083506588126
schizophrenia:3404081083265896111141178217256277311349364396408
a765408108332
systematic8144081083265885108142200232254269301
review11324081083215587103138189
and133740810833270109
network14634081083377295148186207238
meta-analysis.171740810835893115148170203241273340418208315477488115128
Lancet.48341820833265103136169191205
202270341820833468101136
Feb85441820833367106
26;399(10327):824–836.9754182083346880115149184203235266299332365384396431465496534570604638652
6.34042800853652
Efthimiou4074282083335176114129187202240278
O,70142820834758
Taipale7754282083326076115148163198
H,98942820834457
Radua106142820833668107145177
J,125442820832436
et130642820833456
al.13784282083324760
Efficacy1454428208332506886118151183217
and168642820833270109
effectiveness1811428208334537210713916417934043810833164101135161187
of53943810833655
antipsychotics6054381083326989104142168199230266304325339370397
in101443810831451
schizophrenia:10774381083255793108136172210248268301338352383395
network14844381083377092144180201230
meta-analyses1726438108357911121441651972342653404481083154673108134
combining48744810833168126165180217232270309
evidence8084481083346682120155193225258
from10794481083184077135
randomised12264481083215491130168226241267301341
controlled157944810833168106127149186201216251290
trials1882448108321425890105130
and34045810833169107
real-world4594581083205485100121172209230245283
data.7544581083386991123135
Lancet90245810833163100132165186
Psychiatry.11014581083346092122160174205226247281290
202414034581083346799131
Feb;11(2):102–111.154645810833265103115144171186219236248277308340373403430457466
7.34046800853645
O‘Donoghue40346810834760107145184222262300337372
B,79346810833548
Piacenza8584681083355082114148186215249
F,112446810833339
Plapp11804681083355082121161
H,135946810834457
et143346810833456
al.15074681083324760
Response15854681083357097136175213240275
rates18774681083215476109136
to34047820832259
sequential41747820832661101139173212233248280296
trials731478208322445991107133
of88247820833857
antipsychotic9584782083316991106145172205236274312334350382
medications135847820835893132147179212234249287326352
according17294782083326495131153191206244283
to34048820832259
algorithms4144882083324786124146161184222280306
or73648820833759
treatment8104882083224377109131189224262283
guidelines11094882083387691130164180195233268295
in141948820831553
psychotic14874882083396598129167206228243275
disorders.177748820833854801181391782133404981083214963
A424498108341
systematic4864981083276087111145204237260275308
review8154981083215688105140192
and102849810833271111
meta-analysis.116049810835893116150173206244277293325353368395409
Schizophr159049810833366104120150187228267289
Res.19004981083357198112
202434050810833468101133
Jun;268:193–204.48850810832462100112147181216229258289321358389423460472
8.34051800853652
Tiihonen4115182083334964102141179214252
J,68251820832437
Taipale7385182083326075114147163198
H,95551820834457
Mehtälä103151820835489128149182197229
J,128051820832436
et133551820833456
al.14105182083324760
Association14895182083416996134167182214236251289327
of183551820833857
Antipsychotic1911518208341793405282083223776103135167205243265280312
Polypharmacy6665282083357288120159198230251310342374408
vs108852820833158
Monotherapy116052820835593131170192230265286319358389
With15635282083587496134
Psychiatric17115282083356194125163179211232254269301
Rehospitalization34053820833570109147174212228250283299314343376398413451490
Among84453820834199138176215
Adults107453820834179117132155182
With12715382083587496134
Schizophrenia.142053820833365103118147184224262283318356371403416
JAMA185153820832464120161
Psychiatry.3405482083356194125163178210232254288298
201965354820833468100130
May79954820835487117
1;76(5):499–507.9325482083344275107126159178190224257292330364398431437
9.34055800853649
Taipale4065582083336176115148163198
H,62055820834557
Tanskanen6945582083326098125155188226261299
A,101055820834155
Tiihonen10815582083335065103141179214252
J.135055820832436
Safety14035582083326584119141175
of159455820833757
Antipsychotic1667558208341791011161551822142462843223405682083223769
Polypharmacy4255682083357288119159198230251310342374408
Versus8495682083356889116154180
Monotherapy104556820835493131169191229264286319358389
in145056820831553
a1518568208332
Nationwide15665682083457799114152191241257296330
Cohort1912568208340773405782083387697122
of47757820833756
61,8895485782083346473110145179
Patients7425782083356789104139177198226
With9835782083577396134
Schizophrenia.113257820833264102117147184223262283317355370402416
Am156257820834199
J1676578208324
Psychiatry.17155782083356194125163178210232253287297
202334058820833468101136
May49158820835587118
1;180(5):377–385.6245882083354373104139159192211223258290324357389424458470
10.21402281085367085
Kane223822820833568107142
JM,23932282083247992
Correll24982282083407799121155170185
CU.26972282083408495
Pharmacologic280522820833573105126185217249286302340380395427
treatment32452282083224377109131189224262284
of354222820833756
schizophrenia.3612228208326589611114017721402382083397798132170186218231
Dialogues23862382083456193108146186224259285
Clin26872382083405570108
Neurosci.281023820834580117139176203235250263
2010;308823820833468100132145
12(3):345–357.32482382083346481115132144179215247284316349382389
11.21402481085366678
Correll22372482083407798120154170185
CU.24412482083408395
What255424820835897129151
are27232482083325387
we282924820835185
looking29332482083145391122138176215
for31672482083185677
in326324820831553
new333424820833873124
antipsychotics?347624820833270921071461732052372753132140258208322376997121
J2277258208324
Clin23162582083405570108
Psychiatry.24392582083356294126164179211232254288298
2011;72275225820833469100128136169203
Suppl297125820833270109148164
1:9–13.31512582083344277115146176188
12.21402680085366783
Abidi22362681083418095134149
S,239726810833345
Bhaskara245526810833573105131161194215248
SM.271526810833387101
From28282681083325289147
chlorpromazine29872681083316984122143183204241299331360376413448
to344826810832158
klozapine-35192681083294583111144183198236271294
--antipsychotic21402781083214477115136151191217250281319358379395427
adverse258327810833271103138159186221
effects28202781083345473107140164191
and302727810833270109
the31522781083226095
clinician’s32632781083314762100115147162194232244269
dilemma.35482781083385368103161219251264
Can214028820834073111
J2266288208324
Psychiatry.23062882083356193125163178210232253287297
2003261928820833468104137
Dec;48(11):749–55.277128820834681114127162197217248276290302335366399437470503515
13.21402980085366883
Leucht224229820833166103135173195
S,245529820833346
Cipriani25192982083405594116132164202217
A,275429820834155
Spineli28282982083327187125160175190
L,303729820833145
et310029820833456
al.31752982083324760
Comparative325429820833976135174207228261283298331365
efficacy3637298208334537188121153214030820833165
and222230820833270109
tolerability23493082083225975109131164203218234249271305
of267230820833756
15274630820833464
antipsychotic28283082083327091106146172205236274313334350382
drugs32283082083385997136162
in340830820831553
schizophrenia:347830820832659971121411782182562773112140318108338538597
a2258318108332
multiple-treatments231031810835895111133149188204239262284306340372394452488526547575
meta-analysis.290631810835792115148170203241273289321348363389402
Lancet.332931810833165103135169192205
2013355531810833468100130
Sep370631810833267107
14;382(9896):951–962.21403281083346577112146180197230265299335353365400434465498532568601614
14.21403380085366985
Uçok224533810834476113144
A,240933810834256
Gaebel248533810834477112152187203
W.270933810835768
Side27973381083334887122
effects29393381083345473108141165193
of315233810833857
atypical32303381083325387128143175208224
antipsychotics:347433810833271921081471742072382763152140348108322376997109
a2264348108332
brief23113481083396176111130
overview.245634810833870104125160176210262272
World274434810835794115131170
Psychiatry.29293481083356294126164179211232254288298
2008324234810833468105140
Feb;7(1):58–62.339734810833367106118151167199214225261295332369402415
15.21403580085366782
Barnes22343581083356788126160187
TR,24333581083326982
Drake25283581083446698128161
R,270135810833549
Paton27623581083356688124162
C,293635810834052
et300135810833355
al.30683581083324759
Evidence-based31403581083326379117151188220253276315347373408447
guidelines3599358108338758912816217719221403681083377298
for22513681083185576
the23403681083215993
pharmacological244636810833876108129187219250287302340379394425458473
treatment29313681083224377108129187221259280
of322436810833756
schizophrenia:32923681083265895110139176215253273307345359391403
Updated37073681083448221403781083386991124163
recommendations23153781083205486122179236271308347378399414452489515
from28423781083194077134
the29883781083225994
British3094378108335567193108133171
Association32773781083406894131163178209231245283321
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Psychopharmacology.36983781083356193214038810833169108147186218239297330362399415453493525535
J2688388108324
Psychopharmacol.27253881083356194125163202241280312333392424456493509522
2020326038810833468101135
Jan;34(1):3–78.34093881083245694106141176196227242254289325357390403
16.21403980085366985
Velligan2246398108336688499114153185223
DI,24903981083456174
Sajatovic25843981083326581113135171203219251
M,285639810835468
Hatch29443981083447698129167
A,313139810834155
et320739810833456
al.32833981083324861
Why336439810835796127
do351139810833877
psychiatric360839810833965981291671822140408108332547591123
patients22824081083397294109144182203231
stop25334081083264986126
antipsychotic26784081083327092107146173205237275313335350382
medication?308040810835893132147179212234249287326350
A3450408108341
systematic35114081083265885109142200233254270302
review21404182083215587103137189
of234741820833757
reasons24224182083215587113152190216
for26574182083185678
nonadherence275341820833876114147186224259280314352384418
to319041820832158
medication326741820835792132147179212233249287325
in361141820831452
patients3682418208338719310821404281083347294122
with22834281083506689127
serious2431428108326618298136175201
mental265342810835792131152185201
illness.2874428108315304684119146173186
Patient30814281083356789104139178199
Prefer33014281083355690110144166
Adherence.348742810834180118153175209247279313326
2017214043810833468100129
Mar228543810835487108
3;11:449–468.24084381083344676104112147183217254291327363376
17.21404480085366876
Achtyes223044820834172110132166200227
E,247044820833246
Simmons252944820833247105162201239266
A,280844820834155
Skabeev28764482083326296135170206238
A,312744820834155
et319544820833457
al.32654482083324760
Patient33384482083356789104139177198
preferences3549448208339619511414816920424221404582083316592
concerning225145820833269107139173194233248286325
the25954582083226095
efficacy2710458208334527088120153185219
and294845820833270109
side-effect30774582083264180115138174194213247280304
profile34014582083386097115132147182
of360345820833756
schizophrenia36794582083265896111214046820832865105144165199237252284
medications:243746820835792132147179212234249287325352364
a2814468208332
survey28594682083266485119154185
of305746820833857
patients31274682083397293109143181203231
living3371468208315296278116155
with35394682083506688127
schizophrenia.36794682083265896111214047820832865105144165199237252284297
BMC245347820833590131
Psychiatry.25994782083356194125163178210232253288298
2018291247820833468100131
Sep305847820833368107
12;18(1):292.31804782083346477107138157189203215250284317330
18.21404880085366985
Hofer224348820834482102136157
A,241848820834155
Kemmler249148820833569127185201236257
G,276648820834357
Eder284148820833271105127
U,298648820834354
et305848820833456
al.31324882083324860
Quality321048820834786118133148171204
of343248820833857
life3507488208315304983
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schizophrenia:36794882083265896111214049810832968109150172207247263297310
the24734981083226298
impact259449810831575116151184210
of282749810833858
psychopathology,290849810834068102135175215256291313353393410450491525535
attitude3466498108333568298121161202238
toward372749810832261214050810835185106145
medication,230650810835894134149182215237253292331344
and267150810833271110
side28025081083274281117
effects.29405081083345474108142166195209
J3169508108325
Clin32155081083405671110
Psychiatry.33465081083356295127166181214236258292303
2004367050810833469106143
Jul;65(7):932–939.2140518108324627789125159176211230242277310343377412445478489
19.21405280085377186
Foot224852810833372113136
C.240652810834156
Gilburt24845281083456178118158180206
H,271352810834559
Dunn279552810834686126165
P,298352810833641
et304752810833558
al.31285281083334963
People321352810833671112153170206
in344252810831554
control351952810833271111134156195212
of375352810833959
their21405381083226095110131
own228953810833788127
health243353810833873104120142180
and263153810833270109
care.27575381083326486120132
The290653810833372107
King’s30315381083355189128141166
Fund.321553810833268106145158
4.339153810833447
11.34555381083346271
2014.354453810833468100131144
Dostupné37055381083458421405481083275089129169204
na:23665481083387184
https://assets.kingsfund.org.uk/f/256914/x/7c4051df4c/people_in_control_their_own_health_care_november_2014.pdf.24715481083386085125153166193214246273300336359387401433450489529556576616655694708747769808822860891921941965100110371072110711401171119712291257129413222140558108334701051361711912242572853233583974374534885245415796166496877257477688068228598819209559709911026106511161155119212321267129913151337137614131446147915001534157116111649214056810833266124163199220254291325357388400440480499511
20.21405780085367186
Coulter223957810834076114129151184205
A,245757810834054
Collins25245781083397691106121158184
A.272157810834055
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shared30095781083266395116149189
decision-making321057810833872105119145160197235257315347377393431469
a3692578108331
reality.3736578108320542140588108332476184117127
The227958810833371106
King’s23985881083345188127139164
Fund.257558810833268105144157
28.27445881083346881
7.283858810833339
2011.28905881083346899126136
Dostupné303858810834583110133170209247282
na:33325881083386981
https://assets.34265881083375983122148160187207237263289324346373387
kingsfund.org.uk/f/256914/x/73b4098901/making_shared_39402281083294683122148168206244282295333354392405442472501520544578613647680712743768798826861895933969100510401075110911441176119712531285131513311369140714441472151015421563159616361673
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Canadian404324810834073111144183199231269
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Association.46572481083416996135167183215237252291329343
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practice52462481083396094126150166198232
guidelines.5499248108338769139402581083387389104141176203217
Treatment41752581083335084116138196231269290
of448425810833756
schizophrenia.45592581083265896111140177217255277311349364396409
Can498625810834073111
J5116258108324
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2005547425810833468104139
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Suppl423426820833270109148164
1):7S–57S.4414268208334486093126163196230262275
22.39402780085367187
Tandon40392781083326097135173211
R,426227810833549
Targum43232781083325980118155212
SD,45472781083327687
Nasrallah464627810834476102123155170185216254
HA,49122781083448498
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al.50902781083314659
Treatment51612781083324983114135192227264285
Effectiveness5459278108332506910313539402881083213668102140174200226
in417928810831452
Schizophrenia424328810833264101116145181220258279312350365396
Consortium.465228810833975113139177198222237274331344
Strategies50082881083325374107128161200215249275
for52962881083185576
maximizing53852881083568811913419120639402981083284482121
clinical4074298108331466199114146178194
effectiveness42812981083345372107139163178211245283318345371
in466529810831553
the47312981083216095
treatment48392981083214377108130188223261283
of513529810833756
schizophrenia.52042981083265896111140177217255277311349364395409
J3940308108324
Psychiatr39793081083366294126164179211233254
Pract.42483081083365689121146159
2006442230810833468105140
Nov;12(6):348–363.457830810834483115128158188205238256268304339375412444479512525
23.39403180085367388
Kašpárek40493181083356996135169190224255
T,432531810833342
Ustohal43873181083457094131170203218
L.462631810833246
Léčba46923181083326699139172
akutní488531810833262101124162178
epizody50833181083357490119157197229
schizofrenie.533331810832659971131421801992222563940328108337528698
Psychiatrická40513281083346092123161175207228249265296326359
společnost442232810832665103119153185222260287309
ČLS474432810833970104
JEP,4861328108324579196
2018.49693281083346899130143
Dostupné512432810834583110132170208246281
na:54173281083376981
https://postupy-pece.psychiatrie.cz/specialni-psychiatrie/551132810833758823940338108340698311213417421624527031035238641045249052556157561864768171575677380783185487290992395799010201046108811261161117812121229127012861311135313821417145114911508154215661590160716441672
f2-schizofrenie/lecba-akutni-epizody-schizofrenie.39403481083185272991311691842132512702923263643794144404564915245635966186516817197427807958178548939089379751014104610681095112711651180121012471266128813221360137514101422
24.39403580085367186
Howes404035820834482133168195
OD,424935820834793104
Thase436735820833272104131166
ME,454735820835487100
Pillinger466135820833650658095133172207228
T.490335820833342
Treatment49593582083335084116138196231269290
resistance5263358208321558297123146179217249283
in556035820831452
psychiatry:39403682083396598129167182214236258292305
state42603682083264982103137
of441236820833756
the44833682083215994
art45923682083325377
and468436820833270109
new480736820833873124
directions.49453682083385374109141165181219257283297
Mol525636820835593109
Psychiatry.538036820833561931251631782103940378208322437787
2022404237820833569102136
Jan;27(1):58–72.41943782083245694106141174190222236248283318355386421433
25.39403880085357185
Masopust403738810835385111148186223249271
J,432038810832435
Kopecek436738810833471109144175208237
M,461638810835366
Protopopova46943881083355491112147186224262300331363
D.506938810834455
Stabilizacni51363881083325284122137151165193226257294308
a5456388108331
udrzovaci5499388108337759539403981083286597130162178
lé41353981083155050
ba421839810833871
schizofrenie.43073981083265997112141178197219253292307341353
Psychiatrická46783981083356294126164179211232254269301331365
společnost506139810832665104119154187225263290313
ČLS539239810834071106
JEP,5515398108324589397
2022.394040810833468101135148
Dostupné410040810834684111134171210249283
na:43964081083387082
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26.39404280085367085
Hjorth40364281083445895116139176
S.422342810833345
The427942810833371105
More,439542810835491112145156
the45624281083215892
Merrier…?466542810835588109129144178198262285
Antipsychotic49614281083417898113150176208238275312333347378
Polypharmacy53504281083357186116155193224244394043810835789120153
Treatment41084381083334982114135192226264285
Strategies44074381083335374106127160199214248274
in469543810831552
Schizophrenia476243810833264101116144181219257278311348363394
From51714381083325188145
a5331438108332
Pharmacology53774381083367210412418221439404482083316783120159190
Perspective.41444482083356889115153188220244258290324335
Front44934482083325188126147
Psychiatry.46544482083356092123160174206227248281290
2021495844820833468100131
Nov510344820834482113
24;12:760181.52304482083346576106135147180211246277307338347
27.39404580085367180
Siwek40404582083324798133163
M,422345820835468
Chrobak43114582083407899136175208239
AA,45704582083408498
Gorostowicz468845820834382104141168191228279294326357
A,506545820834155
et514045820833456
al.52164582083324760
Kariprazine52964582083356890105144166199228244282317
augmentation394046810833269108165200238260292314329367405
of435846810833756
klozapine44274681083304684112145184200237272
in471246810831552
schizophrenia-a47774681083265896111140177216255276310348363394417449
retrospective5239468108320547698135161200235268292307339373
chart394047810833169102123147
review.41034781083205487102137188199
Front43174781083335290128150
Pharmacol.448247810833573105126184217249286302315
2024481247810833468101133
Jan49604781083245795
4;14:1321112.50704781083344676107119149179212243271298328341
28.39404880085377389
Pillinger404848810833650658095133172207228
T,429648810833342
McCutcheon435748810835688130166189220258293332370
RA,47474881083367993
Vano486048810833668106144
L,502448810833245
et508948810833557
al.51664881083324760
Comparative524648810834077136176209230263284299332367
effects39404981083345372105137161188
of413949810833756
18420749810833464
antipsychotics42834981083316989104142168200231268306327341373399
on469449810833775
metabolic478149810835791113145183221236251282
function50754981083185693124148162200237
in532449810831552
patients53874981083397192107141178199226
with39405081083506485122
schizophrenia,40735081083255692106134169207244264297333347377389
predictors44735081083385891129143173196231251277
of476150810833755
metabolic482650810835790111143180217232246276
dysregulation,51135081083386894113146184220234264285299335372384
and550750810833268106
association39405181083325884121153167199220234272309
with42685181083516688125
psychopathology:44125181083396596127164202241273294332369385422461492505
a4936518108332
systematic49875181083265884106139197228249264295
review53015181083215486101135185
and550551810833269107
network39405281083377293145182203233
meta-analysis.418452810835792113145167198235267281312338352378391
Lancet458652810833164101132165187
Psychiatry.47845281083356192123160174205226247280289
202050855281083346799133
Jan;7(1):64–77.52295281083245593104136151182196207241277313344378383
29.39405380085367285
Masopust404353810835487114152191230256279
J,433953810832537
Mohr439353810835493131152
P,456353810833539
Kopeček462053810833572112147180213244
M.488153810835568
Antipsychotika496753810834179101116155182214246284322344359389423
v5407538108332
léčbě54565381083155082121157
predominantních39405482083396094134172230245283316354375413428460498
negativních445354820833873112145166182214253268300338
příznaků48065482083386075104143175206244
schizofrenie:50655482083265896111140177197219253291306341353
aktualizace543354820833262871251573940558108315305992124157
doporučených411055810833876115154176214246279317347379416
postupů.453955810833977104127165204242254
Psychiatrie.48055581083356194125163178210231253268303315
2020;24(1):40–43.513255810833568101135148183214234265279291325361399436468480
30.39405680085367287
Dollfus404756810834584100115134173199
S,426656810833245
Mach433056810835587120158
C,450756810834053
Morello457956810835593115149165180218
R.481656810833650
Self-Evaluation48865681083326783102123157189222237274307329344382420
of532656810833756
Negative540256810834580119151173188394057820833266
Symptoms:402457820833363121160183220278304317
A4359578208341
Novel441957820834483115149165
Tool460257820833367105121
to474257820832158
Assess48195782083416995130157184
Negative502157820834580120152174189221256
Symptoms.529557820833362121160182219278304318
Schizophr394058820833265103118147184224262283
Bull.42395882083357388103116
2016437158820833468100131
May;42(3):571–8.451758820835587118131166198216249266278314347380412448462
Peter174866580321528385162
Falkai18156658032132633476066
János171766870321124385364
Kálmánf1787668703215283557708594
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